Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical needs and you can pharmacology out of curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the big part of the newest yellow dye away from turmeric, an Indian spruce that is obtained from the newest rhizome of your own exotic plant Curcuma longa, and therefore is one of the Zingiberaceae family unit members. Inside chapter, i discuss the pharmacological facts from curcumin and you may speak about the molecular basics for these activities. We following review the fresh new confirmed and you may potential clinical spends from curcumin. Curcumin is famous historically because the a healing broker, however, its method out of action try in depth. The newest pharmacological negative effects of curcumin be seemingly the consequence of an excellent synergism of sites out of weak biochemical relationships with several physical aim in the interconnected signaling paths. Such plans tend to be nutrients eg cyclooxygenase, lipoxygenase and you may protein kinases, and you will transcription products such as for example NF-?B, STAT and you can Nrf2. Modulation ones molecules has an effect on downstream affectors which make the latest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you can antimicrobial activities regarding curcumin. These consequences was basically checked-out inside the scientific examples of curcumin having pain and inflammatory disease, cancer, Alzheimer problem, aerobic illness, and you can all forms of diabetes. The newest samples purchased varying amounts off curcuminwith additional frequencies and you can duration, to the standard end that high dosage out-of curcumin at the quantity of g are required to obtain healing effects. Find out more
Curcumin: Synthesis, Emerging Part when you look at the Problems Management and you may Wellness Ramifications
Guide Part Samples of bush-derived pharmaceuticals having get to be the notice regarding continuous and great look and invention notice provides, at this point, started quite scarce. After a long period, the very last twenty years was in fact described as a beneficial 100-bend escalation in the number of medical content penned per year you to definitely is from importance on access to curcumin for the biomedicine. Find out more
Design, synthesis and you will biological points out of curcumin prodrugs
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many prospective pharmacological outcomes and can even features therapeutic software in several condition states, once the chatted about in more detail in the earlier chapter. Yet not, the potential health-related effectiveness out https://internationalwomen.net/da/varme-indiske-kvinder/ of curcumin is bound by the the physicochemical attributes away from bad water solubility and you will imbalance, and this end in low bioavailability. Prodrugs out of curcumin bring ways to upgrade of your own biopharmaceutical and pharmacokinetic services, and may even enable it to be exploitation of your own pharmacological effects of curcumin. Within this chapter, i earliest comment the newest physicochemical and you will pharmacokinetics from curcumin. I following define the design of curcumin prodrugs having enhanced water solubility and you may improved chemical compounds stability which can be converted back again to 100 % free curcumin up on bioactivation for the vivo. I high light latest achievements in this field, having a concentrate on the structure, synthesis and you can testing of prodrugs predicated on promoieties in addition to amino acids, fatty acids, nucleic acids, dicarboxylic acids, and polymeric information like hyaluronic acid and polyethylene glycol. So it section has got the basis for optimisation of your physicochemical and you can biopharmaceutical properties therefore the physical factors away from curcumin prodrugs, to your mission using of these curcumin types when you look at the logical applications. Read more
